Effects of Viagra in People Who Suffers Type 2 Diabetes

All the patients exhibited upright disfunction but had no overt evidence of heart disease.

Patients were recruited for the get hold of after approval by the Institutional Review identity card and after giving informed consent (Desouza, Parulkar, Lumpkin, Akers and Fonseca, 2002, 1337). They had a recollect age of 44 +/- 7 years, type 2 diabetes, and erectile dysfunction. They had mean systolic and diastolic blood constricts of 128 +/- 8 and 84 +/- 6 mmHg; fasting glucose levels were 168 +/- 21 mg/dl, and glycosylated hemoglobin levels were 8.4 +/- 1.1 g%. Fasting tryglyceride levels were 232 +/- 42 mg/dl, fasting HDL cholesterol was 35 +/- 6 mg/dl, and fasting LDL cholesterol was 124 /- 18 mg/dl. No patients were included in the resume if they were taking nitrates, had taken sildenafil in the last 3 months, or had hepatic or renal failure.

Patients in the essay were randomly assigned to unmatched of two treatment conferences: one group authoritative 25 mg sildenafil and the opposite group received a placebo which looked identical to the sildenafil (Desouza, Parulkar, Lumpkin, Akers and Fonseca, 2002, 1337). baseline measurements of FMD were obtained, and then the sildenafil or placebo was given. Exactly one arcminute later. FMD was measured once again. The assigned treatment was then continued, given in one daily dose, for 14 days. Twenty-four hours after administratio

The FMD measurements were conducted using a noninvasive proficiency previously described and known to be reliable (Desouza, Parulkar, Lumpkin, Akers and Fonseca, 2002, 1338). vapid ultrasound images were utilise to measure the diameter of the brachial arterial blood vessel with the aid of a 7.0 MHz linear array transducer and a standard 128XP/10 system. A pneumatic tourniquet was used to induce reactive hyperemia by increasing pressure to 220 mmHg for five minutes.

Reactive hyperemia was measured by scans begun 30 seconds before, and continuing for 90 seconds after, deflation of the tourniquet. The maximal brachial arteria diameter (BAD) was recorded during these measurements, and the FMD calculated as a percentage commute in the BAD. Data comparing the sildenafil group to the placebo group were analyzed using the Student's t-test, and pre- and post-occlusion data were compared using the paired t-test with p<0.01 considered significant.

n of the last dose, the patients returned to the laboratory for a repeat measurement of FMD. later on a two-week washout period, the groups were crossed over, and the placebo group now received sildenafil, while the sildenafil group now received placebo, and the tests were again repeated after 24 hours and after two weeks.

Desouza, C., Parulkar, A., Lumpkin, D., Akers, D., & Fonseca, V. A. (2002); corking and prolonged effects of sildenafil on brachial artery flow-mediated dilatation in type 2 diabetes. Diabetes Care, 25(8):1336-1340.

Because only a very small number of patients were examined in this study, a
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